The Evidence for Saffron, Mood Disorders and Mild Anxiety

Saffron is one such amazing spice. Harvested from the dried stigma of the Crocus Sativus, saffron has long held the reputation for being the world’s most expensive spice. Although this high price is due to the extremely labour-intensive process of harvesting the stigmas, research is beginning to unveil some health properties of consuming saffron that, to many people, will be worth a lot more than the cost of this humble spice.


The Evidence for Saffron

Saffron has been found to have numerous therapeutic properties, including and anti-anxiolytic qualities. (1)  A systematic review and meta-analysis (the highest level of evidence in scientific research) found that saffron supplementation significantly reduced symptoms of depression and anxiety when compared with a placebo, and also had a positive effect on depressive symptoms when used in conjunction with anti-depressants. (4) Adolescents with mild-to-moderate depression and anxiety also noticed a significant improvement in their symptoms after supplementing with affron (a saffron extract) for eight weeks. (3) 


Physiologic and Neurologic Effects

There is evidence that saffron may have a positive effect on the body’s monoaminergic and glutamatergic systems. It seems that saffron does this by increasing the reuptake inhibition of dopamine and norepinephrine. (1) Saffron and its active constituents are also NMDA receptor antagonists, and GABA-a-agonists, and have been shown in animal studies to  have a positive effect on the neurotrophin, brain-derived neurotrophic factor (BDNF). (1, 3) 



Safety Profile

Saffron doesn’t interact negatively with other medications, unlike St John’s Wort (3) It has been show to calm the mind and reduce mild anxiety in children 12+ years. These effects have not been studied on children less than 6 years. Saffron has been assessed for tolerability in children 6+ years, with 20mg being the dose used for kids <30kg. 


In Conclusion…

Saffron packs a powerful punch in the emerging world of evidence-based complementary medicine. The evidence to date clearly shows an exciting range of potential health benefits from saffron supplementation and high tolerability. 



1. Baziar S, Aqamolaei A, Mortazavi SH, Naderi S, Sahebolzamani E, Mortezaei A, et al. Crocus sativus L. Versus Methylphenidate in Treatment of Children with Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind Pilot Study. Journal of Child and Adolescent Psychopharmacology. 2019;29(3):205-12.

2. Levy T, Kronenberg S, Crosbie J, Schachar RJ. Attention-deficit/hyperactivity disorder (ADHD) symptoms and suicidality in children: The mediating role of depression, irritability and anxiety symptoms. Journal of Affective Disorders. 2020;265:200-6.

3. Marx W, Lane M, Rocks T, Ruusunen A, Loughman A, Lopresti A, et al. Effect of saffron supplementation on symptoms of depression and anxiety: a systematic review and meta-analysis: Oxford University Press; 2019.

4. Lopresti AL, Drummond PD, Inarejos-García AM, Prodanov M. affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study. Journal of Affective Disorders. 2018;232:349-57.


Written By Brittany Darling




Brittany Darling
Tags: Saffron